Argatroban, Injection

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KEY POINTS

• This medicine is given by infusion to prevent or treat blood clots in people who have had a severe reaction to heparin.
• This medicine increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, or when using sharp objects.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: anticoagulant (medicine that reduces the chance of blood clots forming); direct thrombin inhibitor

Generic and brand names: argatroban, injection

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein). It is used to prevent or treat blood clots in people who have had a severe reaction to heparin, another type of anticoagulant.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Bleeding disorders
• High blood pressure
• Liver disease
• Ulcers

Also tell your provider if you have recently had surgery for brain, spinal cord, or eye problems, of if you have had a lumbar puncture.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while receiving this medicine without your healthcare provider's approval.

How do I use it?

This medicine is usually given while you are in the hospital. You will be monitored closely while receiving this medicine.

After you go home from the hospital, follow directions exactly for any medicines that your healthcare provider may prescribe (such as warfarin). Do not stop taking any medicine or change your dosage without the approval of your healthcare provider.

What should I watch out for?

Bleeding is a common side effect while taking this medicine. Use a soft bristle brush or mouth swab to brush your teeth. If you have any bleeding after you go home from the hospital, put pressure on the area that is bleeding. If that does not stop the bleeding, contact your healthcare provider right away or get emergency medical care.

You will need to have lab tests regularly to see how this medicine affects you. Keep all appointments for these tests.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Serious bleeding that cannot be stopped by applying pressure to the spot that is bleeding; sudden weakness, numbness, or tingling, especially on one side of your body; sudden or severe headache; sudden trouble with vision, speech, balance, or walking.

Serious (Report these to your healthcare provider right away.): Unusual bruising or bleeding; black or tarry bowel movements; blood in your urine or vomit; slow, fast, or irregular heartbeat; chest pain; severe dizziness or fainting; shortness of breath; severe flushing; unusual tiredness or weakness.

Other: Back pain, dizziness, fever, diarrhea, nausea, vomiting, cough, swelling or pain at the injection site.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these medicines together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Anagrelide (Agrylin)
• Antidepressants such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), sertraline (Zoloft), and venlafaxine (Effexor)
• Aspirin and other salicylates
• Cancer medicines such as dasatinib (Sprycel) and omacetaxine (Synribo)
• Medicines to treat or prevent blood clots such as abciximab (ReoPro), alteplase (Activase), cilostazol (Pletal), clopidogrel (Plavix), dabigatran (Pradaxa), dalteparin (Fragmin), dipyridamole (Persantine), dipyridamole/aspirin (Aggrenox), enoxaparin (Lovenox), eptifibatide (Integrilin), fondaparinux (Arixtra), heparin, lepirudin (Refludan), prasugrel (Effient), reteplase (Retavase), rivaroxaban (Xarelto), tenecteplase (TNKase), tirofiban (Aggrastat), vorapaxar (Zontivity), and warfarin (Coumadin)
• Medicines to treat pulmonary hypertension such as epoprostenol (Flolan, Veletri), iloprost (Ventavis), and treprostinil (Remodulin, Tyvaso)
• Natural remedies such as alfalfa, angelica, anise, arnica, bilberry, bladderwrack, bromelain, capsicum, cat's claw, celery, chamomile, clove, evening primrose, fenugreek, feverfew, fish oil, garlic, ginger, ginkgo, ginseng, green tea, horse chestnut, horseradish, licorice, passionflower, red clover, SAMe, turmeric, and willow
• Nonsteroidal anti-inflammatory medicines (NSAIDs) such as celecoxib (Celebrex), diclofenac (Cambia, Voltaren, Zipsor), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen, ketorolac, nabumetone (Relafen), naproxen (Aleve, Anaprox, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)
• Paroxetine (Brisdelle, Paxil, Pexeva)
• Pentosan (Elmiron)
• Tipranavir (Aptivus)
• Vitamin E or multivitamins that contain vitamin E

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.