Atezolizumab, Injection

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KEY POINTS

• This medicine is given by IV to treat certain types of bladder cancer.
• You may get infections more easily when you are taking this medicine.
• This medicine may cause a severe or life-threatening infusion reaction, serious lung problems, or other unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antineoplastic (anticancer)

Generic and brand names: atezolizumab, injection; Tecentriq

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein) to treat certain types of bladder cancer when other anticancer medicines are not effective.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine, food, preservative, or dye
• A weakened immune system from chemotherapy or radiation therapy, diseases such as HIV/AIDS, or from taking steroid medicines or medicines to prevent organ transplant rejection
• Crohn’s disease, ulcerative colitis, or severe diarrhea
• Diabetes
• Liver problems
• Lung or breathing problems such as asthma, COPD, or sleep apnea
• Lupus
• Myasthenia gravis, Guillain-Barré syndrome, or other conditions that affect your nervous system
• Thyroid problems

Also tell your provider if you have any kind of infection.

Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your healthcare provider. Do not become pregnant during treatment with this medicine. Use an effective birth control method while you are taking this medicine and for 5 months after stopping it. If you become pregnant while receiving this medicine or within 5 months after your last dose, contact your healthcare provider right away. Do not breast-feed a baby during treatment with this medicine and for 5 months after your last dose.

How do I use it?

Your healthcare provider will give you these infusions in your provider's office or at a clinic. You will be monitored closely while you are receiving the medicine. Your healthcare provider will tell you how often you will receive these infusions. Keep all appointments for these infusions.

What should I watch out for?

Read the Medication Guide that comes in the medicine package when you start receiving this medicine and each time you receive a treatment.

This medicine may cause a severe infusion reaction. Tell your healthcare care provider right away if you develop chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, fever, feeling like passing out, back or neck pain, and facial swelling.

This medicine may cause severe lung, liver, intestinal, or nervous system problems. Ask your healthcare provider what symptoms you should watch for and what to do if you have them.

You may get infections more easily when you are taking this medicine. Stay away from people with colds, flu, or other infections. Also, do not have any vaccines without getting your healthcare provider's approval first.

You will need to have blood tests regularly to see how this medicine affects you. Keep all appointments for these tests.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you have received this medicine.

You may develop diabetes when you take this medicine. Talk with your healthcare provider about this.

If you have diabetes: Your dosage of insulin or medicines taken by mouth for diabetes may need to be changed. If you are controlling your diabetes with diet and exercise, you may need to start taking medicine. Talk to your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): New or worsening cough or shortness of breath; unexplained fever or sore throat; mouth sores; severe tiredness or weakness; fast or irregular heartbeat; chest pain; unusual bruising or bleeding; bloody, black, or tarry bowel movements; unexplained weight gain or weight loss; severe dizziness or fainting; light-colored bowel movements; dark urine; unexplained loss of appetite; yellowing of the eyes and skin; severe nausea or vomiting; painful urination or urinating more often than usual; eye pain or vision problems; extreme sensitivity to light; neck stiffness; numbness or tingling in hands or feet; confusion or changes in mood or behavior; severe or ongoing headache; severe constipation, diarrhea, or stomach pain; severe back pain; unexplained swelling; severe rash; seizures.

Other: Constipation, nausea, vomiting, decreased appetite, tiredness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Cancer medicines such as cyclophosphamide (Cytoxan), daunorubicin (Cerubidine), doxorubicin (Doxil), epirubicin (Ellence), idarubicin (Idamycin), mitoxantrone (Novantrone), paclitaxel (Abraxane, Taxol), and trastuzumab (Herceptin)
• Echinacea
• Fingolimod (Gilenya)
• Medicines to treat psoriasis, rheumatoid arthritis, and other immune disorders such as leflunomide (Arava), and tofacitinib (Xeljanz)
• Natalizumab (Tysabri)
• Vaccines

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.