Avibactam/Ceftazidime, Injection

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KEY POINTS

• This medicine is given by IV to treat certain infections caused by bacteria.
• Contact your healthcare provider right away if you develop severe diarrhea, or diarrhea that last more than 2 or 3 days, while you are receiving treatment or for several weeks after you stop treatment.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: beta-lactamase inhibitor/cephalosporin antibiotic

Generic and brand names: avibactam/ceftazidime, injection; Avycaz

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein) to treat certain infections caused by bacteria. It will not cure infections caused by viruses, such as colds and the flu.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Kidney disease

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

This medicine is usually given by a healthcare provider in a hospital or clinic. This medicine is given by IV infusion (slow drip through a needle into a large vein). You must have all the infusions your healthcare provider prescribes or the infection may return. Keep all of your appointments.

Sometimes this medicine may also be given at home. When using this medicine at home, be sure you know exactly how and when to use it. Ask your healthcare provider or pharmacist about anything you do not understand.

What should I watch out for?

Contact your healthcare provider if your condition does not improve in a few days or gets worse.

If you receive this medicine for a long time, you may need to have blood tests to see how this medicine affects you. Keep all appointments.

This medicine may cause or worsen diarrhea. Contact your healthcare provider right away if you develop severe diarrhea, or diarrhea that lasts more than 2 or 3 days, while you are receiving treatment or for several weeks after you stop treatment. Do not take medicine to treat diarrhea without your provider's approval.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Fever; yellowish skin or eyes; severe or constant diarrhea; severe stomach pain; bloody or black tarry bowel movements; bloody urine; decreased or trouble urinating; unusual bruising or bleeding; unusual tiredness or weakness; unusual confusion; hallucinations; severe blistering or peeling skin; stiff muscles; tremors or unusual muscle movements; seizures.

Other: Nausea, vomiting, constipation, dizziness, anxiety, pain or redness at the injection site.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking any other medicines.

• Antibiotics such as amikacin, chloramphenicol, gentamicin, neomycin (Neo-Fradin), streptomycin, and tobramycin
• Hormonal birth control implants, IUDs, patches, pills, shots, and vaginal rings (Talk to your healthcare provider if you need birth control.)
• Probenecid
• Warfarin (Coumadin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.