Capreomycin, Injection

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KEY POINTS

• This medicine is given by injection to treat tuberculosis.
• You may get infections more easily when you are taking this medicine.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine can affect your hearing and balance or cause other unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antibiotic

Generic and brand names: capreomycin, injection; Capastat Sulfate

What is this medicine used for?

This medicine is given by injection (shots), usually with other medicines taken by mouth, to treat tuberculosis.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before using this, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicines, especially antibiotics
• Hearing problems
• Kidney disease

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

These shots are given by your healthcare provider. It may be given as a shot into a muscle or as an IV infusion (slow drip through a needle into a vein). Because you may need to take medicine for a long time, your healthcare provider may have you switch from shots to medicine you can take by mouth.

Sometimes you can give yourself these shots or have someone at home give them to you. Your healthcare provider will teach you how to use this medicine at home. Check the label on the medicine for directions about your specific dose. Be sure you know how and when to have shots and how much medicine to use. Do not stop using this medicine without your healthcare provider's approval. Carefully follow the instructions for using this medicine. If you are not sure how to use this medicine, ask your healthcare provider for help.

Discard the needles as instructed by your healthcare provider. Use each needle only once. Throw them away after use in rigid puncture-resistant containers with lids or caps, such as heavy plastic bleach bottles with screw caps. Do not throw them directly into garbage cans or dumpsters.

Check with your healthcare provider before using this medicine in children under the age of 18.

If your healthcare provider has prescribed other medicines, follow his or her instructions exactly. Take all your medicines regularly as prescribed, even if you feel better. Take them for as long as your healthcare provider prescribes.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: hearing problems, ringing in your ears, dizziness, or urinating less than usual.

What should I watch out for?

While you are being treated with this medicine, you will need to have regular lab tests and hearing tests to see how this medicine is affecting you. Keep all your appointments for these tests.

This medicine can affect your hearing and balance. Contact your healthcare provider right away if you notice ringing in your ears, hearing loss, severe dizziness, or trouble keeping your balance.

This medicine may make you dizzy. Do not drive or operate machinery unless you are fully alert.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

You may feel pain or burning at the site of injection. Contact your healthcare provider if it becomes severe.

Contact your healthcare provider if your condition does not improve in a few days or if it gets worse.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Blood in your urine, decreased or increased urination, increased thirst, hearing loss, ringing in the ears, severe dizziness, trouble keeping your balance, muscle weakness, unusual bruising or bleeding, fever, sore throat, severe pain or bleeding at injection site.

Other: Nausea, vomiting, mild pain or bleeding at injection site.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Amphotericin b (Abelcet, AmBisome, Amphotec)
• Antibiotics such as amikacin, colistimethate (Coly-Mycin), gentamicin, kanamycin, neomycin (Neo-Fradin), paromomycin, penicillin, polymyxin B, rifampin (Rifadin), streptomycin, tobramycin, and vancomycin (Vancocin)
• Antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), didanosine (Videx), efavirenz (Sustiva), efavirenz/emtricitabine/tenofovir (Atripla), emtricitabine/rilpivirine/tenofovir (Complera, Odefsey), emtricitabine/tenofovir (Truvada), etravirine (Intelence), famciclovir (Famvir), fosamprenavir (Lexiva), ganciclovir (Cytovene), indinavir (Crixivan), lamivudine (Epivir, Epivir-HBV), lopinavir/ritonavir (Kaletra), maraviroc (Selzentry), nelfinavir (Viracept), nevirapine (Viramune), ribavirin (Copegus, Rebetol, Ribasphere, Virazole), rilpivirine (Edurant), ritonavir (Norvir), saquinavir (Invirase), stavudine (Zerit), tenofovir (Viread), tipranavir (Aptivus), valganciclovir (Valcyte), and zidovudine (Retrovir)
• Immunosuppressants such as cyclosporine (Gengraf, Neoral, Sandimmune), mycophenolate (CellCept, Myfortic), sirolimus (Rapamune), and tacrolimus (Astagraf, Prograf, Protopic)
• Nonsteroidal anti-inflammatory medicines (NSAIDs) such as celecoxib (Celebrex), diclofenac (Cambia, Voltaren, Zipsor), diflunisal, etodolac, ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen, ketorolac, meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Anaprox, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light. After the medicine is mixed, it may be stored in the refrigerator for up to 24 hours. Discard any unused mixed medicine after 24 hours.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.