Carfilzomib, Injection

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KEY POINTS

• This medicine is given by IV to treat multiple myeloma.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause a heart attack or other heart problems; high blood pressure; severe lung, kidney, liver, brain, or nerve problems; and blood clots or bleeding problems. It may cause other unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antineoplastic (anticancer); chemotherapy; proteasome inhibitor

Generic and brand names: carfilzomib, injection; Kyprolis Injection

What is this medicine used for?

This medicine is given by IV infusion to treat multiple myeloma. It may be used alone or along with other medicines.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Blood clots or bleeding problems
• Diabetes
• Heart disease, heart failure, or heart attack
• Herpes zoster
• Liver or kidney disease
• Low or high blood pressure
• Lung disease or pulmonary hypertension
• Peripheral neuropathy (numbness, tingling, pain, or burning feelings in your feet or hands)
• Problems with dehydration

Females of childbearing age: This medicine is not given during pregnancy because it may harm the baby. Tell your healthcare provider if you are pregnant or plan to become pregnant. Use effective birth control while receiving this medicine and for at least 30 days after you stop treatment. Hormonal birth control may increase your risk for blood clots. If you need advice about birth control, ask your healthcare provider. If you become pregnant while receiving this medicine or within 30 days after your stop this medicine, contact your healthcare provider right away. Do not breast-feed while receiving this treatment.

Males: Use effective birth control while receiving this medicine and for at least 90 days after you stop treatment. If your partner becomes pregnant while you are receiving this medicine or within 90 days after you stop this medicine, contact your healthcare provider right away.

How do I use it?

Your healthcare provider will give you the IV infusions (slow drip through a large vein). Your healthcare provider will explain your dose and treatment schedule. Keep all appointments for treatment.

Your healthcare provider may prescribe other medicines along with this medicine to prevent or decrease side effects. Carefully follow your healthcare provider’s instructions for taking any other medicines. Also follow instructions for when and how much water to drink.

What should I watch out for?

This medicine may cause posterior reversible encephalopathy syndrome, tumor lysis syndrome, and infusion-related reactions. Ask your healthcare provider what symptoms or problems you should watch for and what to do if you have them.

This medicine may cause serious or life-threatening problems such as:

• Heart attack or other heart problems
• High blood pressure
• Lung or breathing problems
• Kidney or liver problems
• Brain or nerve problems
• Blood clots or bleeding problems

Talk with your healthcare provider about the risks and benefits of treatment.

This medicine may lower the number of certain types of blood cells in your body. You may get infections or bleed more easily when you are taking this medicine. Stay away from people with colds, flu, or other infections. Also, do not have any vaccines without getting your healthcare provider's approval first.

This medicine can cause nausea, vomiting, and diarrhea, which can lead to dehydration (loss of too much water from your body). Be careful in hot weather to avoid activities that cause you to sweat heavily. Follow your healthcare provider’s instruction for how much water you should drink while receiving this medicine.

You may feel dizzy or faint when you get up quickly after sitting or lying down. Getting up slowly may help. This medicine may make you dizzy or drowsy, or cause blurred vision. Do not drive or operate machinery until you are fully alert and can see clearly.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

You will need to have blood tests and blood pressure checks regularly to see how this medicine affects you. Keep all appointments.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

If you have diabetes: This medicine may affect your blood sugar level and change the amount of diabetes medicines you may need. Talk to your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reactions (hives, itching, rash, tightness in your chest, swelling of your lips, tongue or throat, trouble breathing); sudden weakness, numbness, or tingling, especially on one side of your body; sudden or severe headache; sudden trouble with vision, speech, balance, or walking.

Serious (Report these to your healthcare provider right away.): Muscle weakness or cramps; numbness, tingling, pain, or burning feelings in the feet and hands; fast or irregular heartbeat; chest pain; trouble breathing or shortness of breath; unusual bruising or bleeding; severe nausea, vomiting, diarrhea, or stomach pain; unexplained swelling, redness, pain, or warmth in your hands, arms, legs, or feet; confusion; seizures; changes in your thoughts or moods; trouble urinating; increased, or decreased urination; dark urine; yellowing of the eyes and skin; unusual tiredness or weakness; unexplained fever, cough, or sore throat; severe dizziness, lightheadedness, or fainting; increased thirst; extreme hunger; unexplained loss of appetite; severe drowsiness.

Other: Mild dizziness; nausea, vomiting, or stomach pain; decreased appetite; mild diarrhea; constipation; mild headache; trouble sleeping; back pain; mild tiredness; nervousness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Hormonal birth control implants, IUDs, patches, pills, shots, and vaginal rings (Talk to your healthcare provider if you need birth control.)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.