Ceftaroline Fosamil, Injection

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KEY POINTS

• This medicine is given by injection or IV infusion to treat infections caused by bacteria. Use it exactly as directed.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: cephalosporin antibiotic

Generic and brand names: ceftaroline fosamil, injection; Teflaro

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein) to treat infections caused by bacteria. It is a kind of antibiotic called a cephalosporin. It does not cure viral infections such as colds and the flu.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Colitis or other diseases of the intestine
• Kidney or liver disease

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

This medicine is usually given by IV infusion by a healthcare provider while you are in the hospital. If you are not staying in the hospital while you get these infusions, keep all your appointments for infusions and blood tests.

Sometimes this medicine may also be given at home. When using this medicine at home, be sure you know exactly how and when to use it. Check the label on the medicine for directions about your specific dose and how to store the medicine. Use this medicine exactly as your healthcare provider prescribes. Do not stop using this medicine without your healthcare provider's approval, even if you feel better. You must receive all injections prescribed or the infection may return.

Check with your healthcare provider before using this medicine in children.

If you are using syringes and needles, use them only once and dispose of them safely. Follow your healthcare provider's instructions for how to dispose of used syringes, needles, and medicine containers.

Ask your healthcare provider or pharmacist about anything you do not understand.

The length of treatment you need depends on how your infection responds to the medicine.

Your healthcare provider may prescribe another antibiotic to be taken by mouth to complete your treatment. If so, follow your healthcare provider's instructions for taking the medicine. Take it for as long as your healthcare provider prescribes, even if you feel better.

What should I watch out for?

This medicine may cause or worsen diarrhea. If you develop severe diarrhea or diarrhea that lasts more than 2 or 3 days while taking this medicine, or for several weeks after you stop taking this medicine, contact your healthcare provider right away. Do not take medicine to treat diarrhea without your provider's approval.

Do not have any vaccines (such as for typhoid) without getting your healthcare provider's approval first. This medicine may affect how well vaccines work.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

If you have diabetes: This medicine may affect urine sugar test results. Talk to your healthcare provider about urine and blood sugar tests while you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Fever; yellowing of your skin or eyes; severe or constant diarrhea; severe stomach pain; bloody or black tarry bowel movements; bloody urine; trouble urinating; unusual bruising or bleeding; unusual tiredness or weakness; unusual confusion; hallucinations; lack of responsiveness; severe blistering or peeling skin; seizures.

Other: Nausea, vomiting, mild diarrhea, constipation, dizziness, pain or redness at the injection site.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Antibiotics such as chloramphenicol, gentamicin, neomycin (Neo-Fradin), streptomycin, and tobramycin
• Diuretics (water pills) such as bumetanide, ethacrynic acid (Edecrin), furosemide (Lasix), and torsemide (Demadex)
• Probenecid
• Vaccines such as typhoid and BCG

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.