Chlorpropamide, Oral

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KEY POINTS

• This medicine is taken by mouth to treat type 2 diabetes when diet and exercise have not controlled blood sugar levels. Take it exactly as directed.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antidiabetic

Generic and brand names: chlorpropamide, oral

What is this medicine used for?

This medicine to taken by mouth to treat type 2 diabetes when diet and exercise have not controlled blood sugar levels. This medicine may be used alone or along with other diabetes medicines.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Diabetic ketoacidosis or diabetic coma
• G6PD deficiency
• Heart problems
• Kidney or liver disease
• A thyroid, pituitary, or adrenal gland disorder

Also tell your healthcare provider if you currently have an infection, severe injury, or are scheduled to have surgery. Your medicine may need to be adjusted.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval. Your healthcare provider may prescribe insulin during pregnancy and breast-feeding as a safer way to control blood sugar levels.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes, at the same time every day. Do not stop taking this medicine without your healthcare provider's approval. Check with your healthcare provider before using this medicine in children under age 18. Do not miss doses or take more than prescribed.

Take this medicine with your first meal of the day.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: hunger, nausea, anxiety, blurred vision, sweating, extreme weakness, drowsiness, fainting, tremors, stomach pain, confusion, seizures, coma.

What should I watch out for?

Some medicines used to treat diabetes have been shown to increase the risk of heart disease. It is not known if this medicine increases your risk. Talk with your healthcare provider about this.

Usually you will take this medicine while you follow a diet and exercise program prescribed by your healthcare provider.

Test your blood sugar on the schedule your provider recommends and keep track of it. See your provider regularly for an A1c test to check the average of your blood sugar over 2 to 3 months. This average is different from your day to day blood sugar. Keep all appointments for these tests.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

Talk to your healthcare provider before you take other medicines, including nonprescription products. Do not drink alcohol while taking this medicine unless your healthcare provider approves.

Low blood sugar (hypoglycemia) can happen if you miss or delay meals, drink too much alcohol, take too much medicine, or exercise more than usual. Symptoms of low blood sugar include shaking, anxiety, cold sweats, irritability, fast heartbeat, feeling faint, strong hunger, vision problems, headache, nausea, slurred speech, confusion, unusual mood changes, tingling in the lips or tongue, and weakness. It is a good habit to carry glucose tablets or gel to treat low blood sugar. You can also eat honey or candy, or drink a glass of orange juice or nondiet soda to quickly raise your blood sugar level. Do not use chocolate because the fat content slows down the sugar entering the bloodstream.

This medicine may make your skin more sensitive to the sun and may make you sunburn more easily. Wear protective clothing and sunscreen lotion when you are exposed to the sun. Do not use a sunlamp. If you get a severe sunburn, contact your healthcare provider right away.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine. Carry an ID card or medical ID bracelet saying that you have diabetes. If you are unconscious, this makes sure that emergency healthcare providers know that you are a diabetic and need special care.

This medicine may cause vision problems, drowsiness, or dizziness. Do not drive or operate machinery unless you are fully alert.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat); seizures, fainting.

Serious (Report these to your healthcare provider right away.): Symptoms of hypoglycemia (shaking, anxiety, cold sweats, irritability, fast heartbeat, feeling faint, strong hunger, vision problems, headache, nausea, slurred speech, confusion, unusual mood changes, tingling in the lips or tongue, weakness); unusual tiredness or weakness; dark urine; fever; sore throat; unusual bruising or bleeding; light-colored bowel movements; yellowing of your skin or eyes; fast or irregular heartbeat; severe or ongoing headache; severe nausea or vomiting; severe dizziness; severe skin redness, blisters, or peeling.

Other: Heartburn, diarrhea, mild nausea or vomiting, mild headache, mild dizziness, loss of appetite, rash, itching, sensitivity to the sun, constipation, gas, weight gain.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• ACE inhibitors such as benazepril (Lotensin), captopril, enalapril (Vasotec), fosinopril, lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik)
• Alcohol
• Androgen hormones such as danazol, methyltestosterone (Android, Testred), and testosterone (Androderm, AndroGel, Axiron, Testim)
• Angiotensin receptor blockers (ARBs) such as azilsartan (Edarbi), candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), and valsartan (Diovan)
• Antiarrhythmic medicines (to treat irregular heartbeat) such as amiodarone (Cordarone, Pacerone) and disopyramide (Norpace)
• Antibiotics such as chloramphenicol, ciprofloxacin (Cipro), clarithromycin (Biaxin), gemifloxacin (Factive), isoniazid, levofloxacin (Levaquin), linezolid (Zyvox), moxifloxacin (Avelox), ofloxacin, rifampin (Rifadin), and tetracycline
• Antidepressants such as amitriptyline, amoxapine, citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), escitalopram (Lexapro), fluoxetine (Prozac), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), sertraline (Zoloft), and trimipramine (Surmontil)
• Antifungal medicines such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Monistat, Oravig), posaconazole (Noxafil), and voriconazole (Vfend)
• Antipsychotic medicines such as chlorpromazine, clozapine (Clozaril, FazaClo), olanzapine (Zyprexa), perphenazine, prochlorperazine (Compro), thioridazine, and trifluoperazine
• Antiseizure medicines such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), phenobarbital, phenytoin (Dilantin, Phenytek), and primidone (Mysoline)
• Aprepitant (Emend)
• Aspirin and other salicylates
• Beta blockers such as acebutolol (Sectral), atenolol (Tenormin), carvedilol (Coreg), labetalol (Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), nebivolol (Bystolic), pindolol, and sotalol (Betapace, Sorine)
• Bosentan (Tracleer)
• Calcium channel blockers such as diltiazem (Cardizem, Cartia, Tiazac), felodipine, nicardipine (Cardene), nifedipine (Adalat CC, Procardia), and verapamil (Calan, Covera, Verelan)
• Cancer medicines such as abiraterone (Zytiga), capecitabine (Xeloda), ceritinib (Zykadia), floxuridine, and fluorouracil (Adrucil, Carac, Efudex, Fluoroplex)
• Cholesterol-lowering medicines such as cholestyramine (Prevalite), colesevelam (Welchol), colestipol (Colestid), fenofibrate (Antara, Fenoglide, Lipofen, TriCor, Triglide), fluvastatin (Lescol), and gemfibrozil (Lopid) (Take this medicine at least 4 hours before taking colesevelam.)
• Clonidine (Catapres, Kapvay)
• Corticosteroids such as betamethasone, dexamethasone, fludrocortisone, hydrocortisone (A-Hydrocort, Cortef), methylprednisolone (Medrol, Solu-Medrol), prednisolone (Omnipred, Orapred, Prelone), and prednisone (Prednisone Intensol)
• Cyclosporine (Gengraf, Neoral, Sandimmune)
• Diabetes medicines such as acarbose (Precose), alogliptin/metformin (Kazano), canagliflozin (Invokana), canagliflozin/metformin (Invokamet), dapagliflozin (Farxiga), dapagliflozin/metformin (Xigduo), dulaglutide (Trulicity), empagliflozin (Jardiance), exenatide (Bydureon, Byetta), insulin, linagliptin (Tradjenta), linagliptin/metformin (Jentadueto), metformin (Fortamet, Glucophage, Riomet), nateglinide (Starlix), pioglitazone (Actos), pramlintide (Symlin), repaglinide (Prandin), saxagliptin (Onglyza), sitagliptin (Januvia), and sitagliptin/metformin (Janumet)
• Diuretics (water pills) such as bumetanide, chlorothiazide (Diuril), chlorthalidone, ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (Microzide), methyclothiazide (Enduron), and torsemide (Demadex)
• Doxepin (Silenor)
• HIV medicines such as delavirdine (Rescriptor), efavirenz (Sustiva), and etravirine (Intelence)
• Hormonal birth control implants, IUDs, patches, pills, shots, and vaginal rings, and hormones such as Estinyl, Estratab, Estrovis, and Premarin
• Liraglutide (Saxenda, Victoza)
• MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
• Medicines to block or prevent stomach acid such as cimetidine (Tagamet), famotidine (Pepcid), omeprazole (Prilosec), and ranitidine (Zantac)
• Medicines to treat breathing or lung problems such as albuterol (ProAir, Proventil, Ventolin), epinephrine (Adrenalin, Asthmanefrin, Auvi-Q, EpiPen), terbutaline, and zafirlukast (Accolate)
• Medicines to treat or prevent blood clots such as pentoxifylline, ticagrelor (Brilinta), and warfarin (Coumadin)
• Natural remedies such as alfalfa, aloe, bilberry, bitter melon, burdock, celery, chromium, fenugreek, garlic, ginkgo biloba, ginseng, glucosamine, kava, licorice, stinging nettle, and willow
• Nonsteroidal anti-inflammatory medicines (NSAIDs) such as celecoxib (Celebrex), diclofenac (Cambia, Voltaren, Zipsor), fenoprofen (Nalfon), flurbiprofen, ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen, ketorolac, meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Anaprox, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)
• Octreotide (Sandostatin)
• Paroxetine (Brisdelle, Paxil, Pexeva)
• Pegvisomant (Somavert)
• Probenecid
• Procarbazine (Matulane)
• Propranolol (Hemangeol, Inderal, InnoPran)
• Psyllium (Take psyllium 2 hours before or 2 hours after you take this medicine.)
• Quinine
• Somatropin (Genotropin, Humatrope, Nutropin, Serostim)
• Sulfa antibiotics such as sulfadiazine, sulfamethoxazole/trimethoprim (Bactrim, Septra), and sulfasalazine (Azulfidine)
• Thyroid medicines such as levothyroxine (Levo-T, Levothroid, Levoxyl, Synthroid, Unithroid), liothyronine (Cytomel, Triostat), liotrix (Thyrolar), and thyroid USP (Armour Thyroid, Nature-Throid)
• Verteporfin (Visudyne)

Many medicines may change how well this medicine controls your blood sugar. Be sure to tell the healthcare provider who prescribed this medicine about any other medicines you are taking, including nonprescription products. Also, tell any other healthcare providers who treat you that you are taking this medicine for diabetes.

Many nonprescription products contain sugar, alcohol, or other ingredients that may interfere with this medicine or increase your blood sugar. Check product labels for warnings for diabetics or ask your healthcare provider or pharmacist for advice.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.