Doxycycline Hyclate, Oral

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KEY POINTS

• This medicine is taken by mouth to treat acne and bacterial infections in many parts of the body. It may also be used to help prevent malaria. Take it exactly as directed.
• If you develop severe diarrhea or diarrhea that lasts more than 2 or 3 days while taking this medicine, or for several weeks after you stop taking this medicine, contact your healthcare provider right away.
• You may be more likely to get fungal infections while taking this medicine.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: tetracycline antibiotic

Generic and brand names: doxycycline hyclate, oral; Acticlate

What is this medicine used for?

This medicine is taken by mouth to treat acne and bacterial infections in many parts of the body. It may also be used to help prevent malaria. It does not cure viral infections such as colds and the flu.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Kidney or liver disease
• Trouble swallowing or esophagus problems

Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. Tell your healthcare provider if you are pregnant or plan to become pregnant. Hormonal birth control may be less effective while you are taking this medicine. Talk to your healthcare provider if you need birth control. Do not become pregnant during treatment with this medicine. If you become pregnant, contact your healthcare provider right away. Do not breast-feed while taking this medicine without discussing with your healthcare provider.

How do I use it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Take it regularly for as long as prescribed, even if you start to feel better. The infection may return if you stop taking the medicine too soon. Do not take more or less than prescribed. Drink plenty of fluids while taking this medicine.

Check with your healthcare provider before using this medicine in children under age 8.

You may take this medicine with or without food. Taking it with meals may lessen the chance the medicine will upset your stomach.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: nausea, vomiting, diarrhea, dizziness, increased urination.

What should I watch out for?

This medicine is usually not given to infants or children younger than 8 years old because it can cause problems with tooth development or permanently discolor teeth.

Do not take this medicine for other infections unless your healthcare provider approves.

This medicine may make you dizzy. Do not drive or operate machinery unless you are fully alert.

If you take this medicine for a long time, you may need to have blood tests regularly to see how this medicine affects you. Keep all appointments.

This medicine may cause or worsen diarrhea. If you develop severe diarrhea or diarrhea that lasts more than 2 or 3 days while taking this medicine, or for several weeks after you stop taking this medicine, contact your healthcare provider right away. Do not take medicine to treat diarrhea without your provider's approval.

You may be more likely to get fungal infections while taking this medicine. Contact your healthcare provider if you notice new symptoms such as white patches in your mouth or a vaginal discharge.

This medicine may make your skin more sensitive to the sun and may cause you to sunburn more easily. While you are taking this medicine, avoid long exposure to the sun. While you are in the sun, wear protective clothing and sunscreen lotion until you know how you will react to the sun. Do not use a sunlamp. If you get a severe sunburn, contact your healthcare provider right away. You may continue to sunburn easily after you stop taking the medicine.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Trouble swallowing, unusual bruising or bleeding, unusual tiredness or weakness, itchy rash or peeling skin; severe or ongoing diarrhea; severe headache; vision problems; yellowing of skin or eyes; dark urine; severe nausea, vomiting, or stomach pain; light-colored bowel movements; unexplained fever or sore throat.

Other: White patches in mouth, vaginal itching or discharge, dizziness, sore mouth, mild nausea or vomiting, mild diarrhea, headache, loss of appetite.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Alcohol
• Antacids or vitamins that contain aluminum, calcium, or magnesium (Take at least 2 hours before or 2 hours after you take this medicine.)
• Antibiotics such as amoxicillin (Amoxil, Moxatag), dicloxacillin, minocycline (Dynacin, Minocin, Solodyn), rifampin (Rifadin), and others
• Antiseizure medicines such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), and phenytoin (Dilantin, Phenytek)
• Barbiturates such as butabarbital (Butisol), pentobarbital (Nembutal), phenobarbital, and secobarbital (Seconal)
• Bismuth subsalicylate (Pepto-Bismol)
• Cholesterol-lowering medicines such as cholestyramine (Prevalite), colesevelam (Welchol), and colestipol (Colestid)
• Digoxin (Lanoxin)
• Hormonal birth control implants, IUDs, patches, pills, shots, and vaginal rings (Talk to your healthcare provider if you need birth control.)
• Lanthanum (Fosrenol) (Take lanthanum at least 2 hours before or 2 hours after you take this medicine.)
• Medicines or supplements that contain iron or zinc
• Methotrexate (Otrexup, Rasuvo, Rheumatrex, Trexall)
• Quinapril (Accupril)
• Retinoid medicines such as acitretin (Soriatane), isotretinoin (Absorica, Amnesteem, Claravis, Myorisan, Zenatane), and tretinoin (Atralin, Renova, Retin-A)
• Sucralfate (Carafate)
• Warfarin (Coumadin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.