Ferumoxytol, Injection

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KEY POINTS

• This medicine is given by IV infusion to treat iron deficiency anemia in people with chronic kidney disease.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: iron supplement

Generic and brand names: ferumoxytol, injection; Feraheme

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein) to treat iron deficiency anemia in people with chronic kidney disease.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine or to iron replacement products
• Liver disease
• Low blood pressure

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

Your healthcare provider will give the first dose of this medicine as an IV infusion, with a second dose about 3 to 8 days later. You will be monitored closely while you are receiving this medicine and for at least 30 minutes after you receive it.

You may need several treatments if your iron deficiency anemia continues or returns. Talk with your healthcare provider about this.

What should I watch out for?

People receiving this medicine often get low blood pressure. You will be watched closely for after receiving this medicine. Tell your healthcare provider if you faint or feel lightheaded, dizzy, weak, or have any other symptoms.

You will need blood tests regularly to see how well your treatment is working and to check that you don't get too much iron. Keep all appointments for tests.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist that you have received this medicine. This medicine may affect MRI results for 3 months after you have taken this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away to get emergency medical care.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Fainting; irregular or fast heartbeat; swelling of your hands, feet, or ankles; chest pain; shortness of breath.

Other: Lightheadedness, nausea, headache, vomiting, diarrhea, constipation, cough, abdominal pain, dizziness, muscle spasms; back pain, swelling, or redness of the injection site.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects.

Do not take iron medicine by mouth if you are also receiving injections unless your healthcare provider approves. Also, check your multivitamin to see if it contains iron. An overdose of iron can be very serious. Talk to your healthcare provider or pharmacist if you have any questions.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.