Ibutilide Fumarate, Injection

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KEY POINTS

• This medicine is given by IV to treat an irregular heartbeat.
• Tell your healthcare provider if your heart rhythm problem seems worse after receiving this medicine. This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• This medicine may interact with many other medicines. Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antiarrhythmic (treats irregular heartbeat)

Generic and brand names: ibutilide fumarate, injection; Corvert

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein) to treat an irregular heartbeat.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Heart failure, or if you take medicines for any heart problem
• Long QT syndrome (problems with electrical activity in the heart muscle)
• Low levels of potassium or magnesium in the blood

Also tell your provider if you have recently had a heart attack.

There are many medicines that should NOT be taken while you are taking this medicine. Do not start or stop any medicine or supplement unless you check with your healthcare provider or pharmacist first.

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

This is a very strong medicine. Only healthcare providers experienced with this drug should prescribe it. It should only be given in a clinic or hospital where you can be monitored closely.

What should I watch out for?

Healthcare providers will constantly monitor your response to this medicine. The dosage will be adjusted depending on your response. Tell your healthcare provider if your heart rhythm problem seems worse after receiving this medicine.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you have received this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; chest pain or tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Fast, slow, pounding, or irregular heartbeat; chest pain or discomfort; severe dizziness or lightheadedness; fainting; trouble breathing.

Other: Headache, nausea.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Alfuzosin (Uroxatral)
• Anagrelide (Agrylin)
• Antiarrhythmic medicines (to treat irregular heartbeat) such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), flecainide, mexiletine, procainamide, propafenone (Rythmol), and quinidine
• Antibiotics such as azithromycin (Zithromax, Zmax), bedaquiline (Sirturo), ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (E.E.S., Ery-Tab, Erythrocin), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin, pentamidine (NebuPent, Pentam), sulfamethoxazole/trimethoprim (Bactrim, Septra), telithromycin (Ketek), and trimethoprim (Primsol)
• Antidepressants such as amitriptyline, citalopram (Celexa), clomipramine, desipramine (Norpramin), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), sertraline (Zoloft), and trazodone
• Antifungal medicines such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend)
• Antihistamines such as diphenhydramine (Benadryl) and hydroxyzine (Vistaril)
• Antipsychotic medicines such as aripiprazole (Abilify), asenapine (Saphris), chlorpromazine, clozapine (Clozaril, FazaClo), fluphenazine, haloperidol (Haldol), iloperidone (Fanapt), olanzapine (Zyprexa), paliperidone (Invega), pimozide (Orap), quetiapine (Seroquel), thioridazine, and ziprasidone (Geodon)
• Apomorphine (Apokyn)
• Cancer medicines such as arsenic trioxide (Trisenox), ceritinib (Zykadia), crizotinib (Xalkori), degarelix (Firmagon), eribulin (Halaven), goserelin (Zoladex), histrelin (Vantas), lapatinib (Tykerb), nilotinib (Tasigna), pazopanib (Votrient), romidepsin (Istodax), toremifene (Fareston), vandetanib (Caprelsa), and vemurafenib (Zelboraf)
• Dextromethorphan/quinidine (Nuedexta)
• Digoxin (Lanoxin)
• Doxepin (Silenor)
• Eliglustat (Cerdelga)
• Ezogabine (Potiga)
• Famotidine (Pepcid)
• Fingolimod (Gilenya)
• Foscarnet (Foscavir)
• HIV medicines such as atazanavir (Reyataz), lopinavir/ritonavir (Kaletra), ritonavir (Norvir), and saquinavir (Invirase)
• Lithium (Lithobid)
• Malaria medicines such as artemether/lumefantrine (Coartem), chloroquine, hydroxychloroquine, mefloquine, primaquine, and quinine
• Medicines to treat breathing or lung problems such as arformoterol (Brovana), fluticasone/vilanterol (Breo Ellipta), formoterol (Perforomist), indacaterol (Arcapta), olodaterol (Striverdi Respimat), and salmeterol (Serevent)
• Methadone (Dolophine, Methadose)
• Mifepristone (Korlym, Mifeprex)
• Mirabegron (Myrbetriq)
• Muscle relaxants such as cyclobenzaprine (Amrix) and tizanidine (Zanaflex)
• Nausea medicines such as dolasetron (Anzemet), droperidol (Inapsine), granisetron (Sancuso), ondansetron (Zofran), and promethazine
• Octreotide (Sandostatin)
• Paroxetine (Brisdelle, Paxil, Pexeva)
• Pasireotide (Signifor)
• Ranolazine (Ranexa)
• Tacrolimus (Astagraf, Prograf, Protopic)
• Tetrabenazine (Xenazine)
• Tolterodine (Detrol)
• Vardenafil (Levitra, Staxyn)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.