Isoproterenol, Injection

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KEY POINTS

• This medicine is given by IV to help the heart pump better in people who have heart disease.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: vasopressor (helps the heart pump better)

Generic and brand names: isoproterenol, injection; Isuprel

What is this medicine used for?

This medicine is given by IV infusions (slow drip into a large vein) to help the heart pump better. You may need this treatment because of heart disease.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine or sulfites (preservatives)
• Angina (chest pain) or heart rhythm problems
• Asthma or other breathing problems
• Diabetes
• Thyroid problems

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while receiving this medicine without your healthcare provider's approval.

How do I use it?

These infusions are given by your healthcare provider, usually in a hospital or other medical facility.

What should I watch out for?

Healthcare providers will constantly monitor your response to this medicine. The dosage will be adjusted depending on your response.

You may need to have lab tests regularly to see how this medicine affects you.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you have received this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; chest pain or tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Chest pain; shortness of breath; slow, fast, or irregular heartbeat; severe dizziness or fainting; swelling of lower legs and ankles.

Other: Irritation at injection site, nausea, vomiting, headache, shakiness, tiredness, weakness, nervousness, dizziness, vision problems, flushing, sweating.

What products might interact with this medicine?

Receiving this medicine while you are taking or receiving shots of other medicines can change the way this or any of the other medicines work. Also, using these medicines together might cause harmful side effects. Talk to your healthcare provider if you are taking any of these medicines:

• Anagrelide (Agrylin)
• Antibiotics such as azithromycin (Zithromax, Zmax), bedaquiline (Sirturo), ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (E.E.S., Ery-Tab, Erythrocin), levofloxacin (Levaquin), moxifloxacin (Avelox), and telithromycin (Ketek)
• Antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), and trazodone
• Antipsychotic medicines such as asenapine (Saphris), chlorpromazine, clozapine (Clozaril, FazaClo), haloperidol (Haldol), iloperidone (Fanapt), paliperidone (Invega), pimozide (Orap), quetiapine (Seroquel), thioridazine, and ziprasidone (Geodon)
• Beta blockers such as acebutolol (Sectral), atenolol (Tenormin), carvedilol (Coreg), labetalol (Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), pindolol, and sotalol (Betapace, Sorine)
• Buprenorphine (Buprenex, Butrans)
• Cancer medicines such as arsenic trioxide (Trisenox), ceritinib (Zykadia), crizotinib (Xalkori), nilotinib (Tasigna), toremifene (Fareston), vandetanib (Caprelsa), and vemurafenib (Zelboraf)
• Cough, cold, or allergy medicines such as ephedrine, naphazoline, oxymetazoline (Afrin, Dristan), phenylephrine (Neo-Synephrine, Sudafed PE), and pseudoephedrine (Sudafed)
• Diet pills such as benzphetamine (Regimex), diethylpropion (Tenuate), phendimetrazine, and phentermine (Adipex-P, Suprenza)
• Diuretics (water pills) such as amiloride, bumetanide, chlorothiazide (Diuril), furosemide (Lasix), hydrochlorothiazide (Microzide), spironolactone (Aldactone), torsemide (Demadex), and triamterene (Dyrenium)
• Doxepin (Silenor)
• Eliglustat (Cerdelga)
• Epinephrine (Adrenalin, Asthmanefrin, Auvi-Q, EpiPen)
• Heart medicines such as amiodarone (Cordarone, Pacerone), bepridil (Vascor), diltiazem (Cardizem, Cartia, Tiazac), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), flecainide, isradipine (DynaCirc), procainamide, propafenone (Rythmol), quinidine, sotalol (Betapace, Sorine), and verapamil (Calan, Covera, Verelan)
• HIV medicines such as lopinavir/ritonavir (Kaletra) and saquinavir (Invirase)
• Malaria medicines such as artemether/lumefantrine (Coartem), chloroquine, primaquine, and quinine
• MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
• Medicines to treat breathing or lung problems such as aminophylline, metaproterenol, and theophylline
• Methadone (Dolophine, Methadose)
• Midodrine
• Mifepristone (Korlym, Mifeprex)
• Natural remedies such as ephedra, ginger, and yohimbe
• Nausea medicines such as aprepitant (Emend), dolasetron (Anzemet), and ondansetron (Zofran)
• Parkinson’s disease medicines such as entacapone (Comtan) and tolcapone (Tasmar)
• Propranolol (Hemangeol, Inderal, InnoPran)
• Stimulants such as amphetamine/dextroamphetamine (Adderall), armodafinil (Nuvigil), dextroamphetamine (Dexedrine), methamphetamine (Desoxyn), and modafinil (Provigil)
• Tetrabenazine (Xenazine)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.