Ivabradine, Oral

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KEY POINTS

• This medicine is taken by mouth to treat heart failure. Take it exactly as directed.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause vision changes, a slow heartbeat, or other unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: nucleotide-gated channel blocker

Generic and brand names: ivabradine, oral; Corlanor

What is this medicine used for?

This medicine is taken by mouth to treat heart failure.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Heart problems such as a very slow heartbeat, or if you have a pacemaker
• Liver problems
• Low blood pressure

Females of childbearing age: Do not take this medicine if you are pregnant. This medicine has been reported to cause birth defects. Use an effective birth control method while you are taking this medicine. Stop taking this medicine at the first sign that you may be pregnant and contact your healthcare provider right away. Do not breast-feed while taking this medicine.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take it exactly as directed by your healthcare provider. Do not take more of it or take it more often than directed. Taking too much of this medicine will increase the chances of side effects. Do not stop taking this medicine without your healthcare provider's approval. You may have to gradually reduce your dosage.

Check with your healthcare provider before using this medicine in children under age 18.

Take this medicine with food.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: very slow heartbeat, chest pain, fainting, dizziness, weakness, tiredness, confusion.

What should I watch out for?

Your provider may want you to check your heart rate and blood pressure regularly while you are taking this medicine. This medicine can increase your blood pressure or cause new irregular heartbeats. Contact your healthcare provider or get medical care right away if you notice a change in your heart rate.

This medicine may cause sudden vision changes such as flashes of light or brightness in your field of vision. This usually happens within the first 2 months of starting the medicine and usually goes away over time. Use caution when operating machinery or driving, especially at night.

Your healthcare provider may want you to have an eye exam before starting this medicine and during treatment to determine if this medicine is affecting your eyes. Keep all your appointments. If you notice changes in your vision such as halos or glare, contact your healthcare provider.

Alcohol and other medicines that slow down your nervous system may add to your side effects. Do not drink alcohol while you are taking this medicine without your healthcare provider's approval.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Slow, pounding, or irregular heartbeat; chest pain; worsening shortness of breath; unusual tiredness or weakness; severe confusion or memory problems; dizziness, or fainting; vision changes.

Other: Mild dizziness, drowsiness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• ACE inhibitors such as captopril, enalapril (Vasotec), fosinopril, lisinopril (Prinivil, Zestril), perindopril (Lotensin), quinapril (Accupril), and ramipril (Altace)
• Antiarrhythmic medicines (to treat irregular heartbeat) such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), dronedarone (Multaq), and quinidine
• Antibiotics such as azithromycin (Zithromax, Zmax), ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (E.E.S., Ery-Tab, Erythrocin), nafcillin, quinupristin/dalfopristin (Synercid), rifabutin (Mycobutin), rifampin (Rifadin), rifapentine (Priftin), sulfamethoxazole/trimethoprim (Bactrim, Septra), telithromycin (Ketek), and trimethoprim (Primsol)
• Antifungal medicines such as clotrimazole, fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend)
• Antipsychotic medicines such as aripiprazole (Abilify), haloperidol (Haldol), pimozide (Orap), quetiapine (Seroquel), and risperidone (Risperdal)
• Antiseizure medicines such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), phenytoin (Dilantin, Phenytek), and primidone (Mysoline)
• Antiviral medicines such as ombitasvir/paritaprevir/ritonavir/dasabuvir (Viekira) and simeprevir (Olysio)
• Aprepitant (Emend)
• Barbiturates such as butabarbital (Butisol), pentobarbital (Nembutal), phenobarbital, and secobarbital (Seconal)
• Beta blockers such as acebutolol (Sectral), atenolol (Tenormin), bisoprolol (Zebeta), carvedilol (Coreg), labetalol (Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), nebivolol (Bystolic), pindolol, and sotalol (Betapace, Sorine)
• Bosentan (Tracleer)
• Calcium channel blockers such as diltiazem (Cardizem, Cartia, Tiazac), felodipine, isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat CC, Procardia), and verapamil (Calan, Covera, Verelan)
• Cancer medicines such as abiraterone (Zytiga), ceritinib (Zykadia), crizotinib (Xalkori), dabrafenib (Tafinlar), dasatinib (Sprycel), enzalutamide (Xtandi), idelalisib (Zydelig), imatinib (Gleevec), nilotinib (Tasigna), and rituximab (Rituxan)
• Cimetidine (Tagamet)
• Conivaptan (Vaprisol)
• Dexamethasone
• Dextromethorphan/quinidine (Nuedexta)
• Digoxin (Lanoxin)
• Diuretics (water pills) such as amiloride, bumetanide, chlorothiazide (Diuril), furosemide (Lasix), hydrochlorothiazide (Microzide), spironolactone (Aldactone), torsemide (Demadex), and triamterene (Dyrenium)
• HIV medicines such as atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir/ritonavir (Kaletra), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), saquinavir (Invirase), stavudine (Zerit) and tipranavir (Aptivus)
• Immunosuppressants such as azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Prograf, Protopic)
• Natural remedies such as black cohosh, cayenne, dong quai, ephedra, garlic, ginseng, goldenseal, hawthorn, St. John’s wort, and yohimbe
• Nefazodone
• Propranolol (Hemangeol, Inderal, InnoPran)
• Stimulants such as armodafinil (Nuvigil) and modafinil (Provigil)

Do NOT eat or drink products that contain grapefruit, Seville oranges, and tangelos at any time while you are taking this medicine. These fruits and juices affect the way this medicine works and increase your risk of serious side effects. Talk with your healthcare provider or pharmacist about this.

Do not drink alcohol while you are taking this medicine without your healthcare provider's approval.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.