Micafungin, Injection

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KEY POINTS

• This medicine is given by IV to prevent certain kinds of fungal infections.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause serious liver problems or other unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antifungal

Generic and brand names: micafungin, injection; Mycamine

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein). It is used to treat or prevent certain kinds of Candida (yeast) fungal infections.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Liver or kidney disease

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

This medicine is given by a healthcare provider as an IV infusion over a period of at least 1 hour. The total number of treatments you need depends on how your infection responds to the medicine.

What should I watch out for?

You will need to have lab tests regularly to see how this medicine affects you. Talk with your healthcare provider about this.

This medicine may cause serious liver problems. If you develop nausea, vomiting, a fever, stomach pain, yellowing of your eyes or skin, or severe fatigue, contact your healthcare provider right away. These may be signs of liver damage. Avoid alcohol while taking this medicine. Alcohol may increase the risk of liver problems.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you have received this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Severe stomach pain; severe diarrhea; fever; yellowing of your skin or eyes; dark urine; light-colored bowel movements; trouble urinating or decreased urination; increased thirst or dry mouth; severe muscle cramps; unusual tiredness or weakness; unusual bruising or bleeding; seizures; numbness or tingling in the arms, legs or body; black or bloody bowel movements; irregular, slow, or fast heartbeat; unexplained swelling of the hands or feet; fainting.

Other: Vomiting; nausea; diarrhea; constipation; flushing; headache; dizziness; chills; blurred vision; pain, burning, or swelling at infusion site; stomach cramps; restlessness; sore throat; loss of appetite, trouble sleeping.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Itraconazole (Sporanox)
• Nifedipine (Adalat CC, Procardia)
• Sirolimus (Rapamune)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.