Nadolol/Bendroflumethiazide, Oral

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KEY POINTS

• This medicine is taken by mouth to treat high blood pressure. Take it exactly as directed. Do not stop taking this medicine without your healthcare provider's approval.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: beta blocker; diuretic (water pill)

Generic and brand names: nadolol/bendroflumethiazide, oral; Corzide

What is this medicine used for?

This medicine is a combination of a beta blocker and a diuretic (water pill). It is taken by mouth to treat high blood pressure.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• A stroke or transient ischemic attack (TIA)
• Asthma, COPD, or other lung problems
• Depression
• Diabetes
• Gout
• Heart failure or any other heart or blood vessel disease
• High cholesterol or high triglycerides
• Imbalances of sodium, potassium, magnesium, or calcium in your blood
• Liver or kidney problems
• Lupus
• Myasthenia gravis
• Pheochromocytoma (a tumor of the adrenal gland)
• Problems with blood circulation such as Raynaud's syndrome
• Psoriasis
• Thyroid problems
• Trouble urinating

Females of childbearing age: Tell your healthcare provider if you are pregnant or if you plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Take it regularly, even if you feel better, to control your blood pressure. Do not stop taking this medicine without your healthcare provider's approval. If your provider has also prescribed another medicine, take it regularly.

Check with your healthcare provider before using this medicine in children under age 18.

You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach.

The diuretic in this medicine increases how much and how often you urinate. Take the last dose of the day by 6 PM to avoid interrupting your sleep at night.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: drowsiness, lightheadedness, increased urination, dry mouth, diarrhea, slow heartbeat, wheezing, trouble breathing, sweating, tremors, weakness, fainting, confusion, seizures, coma.

What should I watch out for?

Do not stop taking this medicine without your healthcare provider's approval. You must reduce your dosage gradually to avoid serious heart-related effects.

You need check your pulse and blood pressure regularly so you can report any unusual slowing of your heart rate or other side effects. You also need to have blood tests regularly to see how this medicine affects you. Keep all appointments for these tests.

If you have any sign of infection, such as a sore throat or fever, contact your healthcare provider.

This medicine may make you dizzy, drowsy, or lightheaded, especially in hot weather. Be careful when exercising. Do not drive or operate machinery unless you are fully alert.

Dizziness may get worse if you lose too much water from your body. You can lose water if you sweat a lot, vomit, or have diarrhea. Tell your provider if you feel dizzy after you have had diarrhea or vomiting. You may feel dizzy or faint when you get up quickly after sitting or lying down. Getting up slowly may help. If you feel dizzy or faint while you are standing, lie down for a while and then get up slowly. Also, drinking alcohol may make it worse. Do not drink alcohol unless your healthcare provider approves.

Talk with your healthcare provider about whether you should eat foods high in potassium such as bananas, melons, raisins, and dates while taking this medicine. Follow the diet and exercise program your healthcare provider recommends.

This medicine may make your skin more sensitive to the sun, which may lead to painful sunburns. While you are taking this medicine, avoid long exposure to the sun. Wear protective clothing, a hat, and sunscreen lotion when you need to be outdoors. Do not use a sunlamp. If you get a severe sunburn, contact your healthcare provider right away.

If you develop hives, an itchy rash, or peeling skin, stop taking the medicine and contact your provider right away.

If you use epinephrine (Epi-Pen) for severe allergic reactions, you may require a higher dose than usual while you are taking this medicine. Talk with your healthcare provider about this.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist that you are taking this medicine.

If you have diabetes: This medicine may affect your blood sugar levels and change the amount of insulin or other diabetes medicines you may need. Also, it may be harder to tell if your blood sugar level is too low. Talk with your healthcare provider about this. Be sure you understand how this medicine might affect you and what to do if you have a problem.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Chest pain; cold hands or feet; severe dizziness or fainting; seizures; unusual restlessness or confusion; memory problems; depression; severe skin rash, redness, blisters, or peeling; fast, slow, or irregular heartbeat; yellowing of your skin or eyes; dark urine; light-colored bowel movements; muscle cramps; swelling of legs or ankles; unexplained weakness or tiredness; severe stomach or back pain; severe diarrhea, nausea, or vomiting; very dry mouth; extreme thirst; trouble urinating or decreased urination; unusual bruising or bleeding; sore mouth or throat.

Other: Dizziness, drowsiness, headache, lightheadedness, tingling in your fingers or toes, loss of appetite, nausea, constipation, diarrhea, trouble sleeping, abnormal dreams, change in sexual ability or desire.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• ACE inhibitors such as benazepril (Lotensin), captopril, enalapril (Vasotec), fosinopril, lisinopril (Prinivil, Zestril), quinapril (Accupril), and ramipril (Altace)
• Aliskiren (Tekturna) and aliskiren/hydrochlorothiazide (Tekturna HCT)
• Allopurinol (Aloprim, Zyloprim)
• Alpha blockers such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), and terazosin
• Alzheimer's disease medicines such as donepezil (Aricept), galantamine (Razadyne), and rivastigmine (Exelon)
• Amifostine (Ethyol)
• Angiotensin receptor blockers (ARBs) such as azilsartan (Edarbi), candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), and valsartan (Diovan)
• Antacids that contain aluminum, calcium, or magnesium, such as Gaviscon, Maalox, Mylanta, Phillips' Chewable Tablets, Rolaids, or TUMS
• Antiarrhythmic medicines (to treat irregular heartbeat) such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), propafenone (Rythmol), and quinidine
• Antibiotics such as azithromycin (Zithromax, Zmax), clarithromycin (Biaxin), erythromycin (E.E.S., Ery-Tab, Erythrocin), and rifampin (Rifadin)
• Anticholinergic medicines such as atropine, benztropine (Cogentin), dicyclomine (Bentyl), glycopyrrolate (Cuvposa, Robinul), hyoscyamine (HyoMax, Levbid, Levsin), methscopolamine (Pamine), propantheline, and trihexyphenidyl
• Antidepressants such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), and sertraline (Zoloft)
• Antifungal medicines such as amphotericin b (Abelcet, AmBisome, Amphotec), itraconazole (Sporanox), and ketoconazole (Nizoral)
• Antipsychotic medicines such as aripiprazole (Abilify), chlorpromazine, haloperidol (Haldol), perphenazine, risperidone (Risperdal), thioridazine, and trifluoperazine
• Antiseizure medicines such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenytoin (Dilantin, Phenytek), and primidone (Mysoline)
• Antiviral medicines such as daclatasvir (Daklinza), ombitasvir/paritaprevir/ritonavir (Technivie), and simeprevir (Olysio)
• Barbiturates such as butabarbital (Butisol), pentobarbital (Nembutal), phenobarbital, and secobarbital (Seconal)
• Calcium channel blockers such as diltiazem (Cardizem, Cartia, Tiazac), nicardipine (Cardene), and verapamil (Calan, Covera, Verelan)
• Calcium supplements
• Cancer medicines such as abiraterone (Zytiga), ceritinib (Zykadia), crizotinib (Xalkori), nilotinib (Tasigna), regorafenib (Stivarga), rituximab (Rituxan), vandetanib (Caprelsa), and vemurafenib (Zelboraf)
• Cholesterol-lowering medicines such as atorvastatin (Lipitor), cholestyramine (Prevalite), colesevelam (Welchol), colestipol (Colestid), and lomitapide (Juxtapid)
• Clonidine (Catapres, Kapvay)
• Corticosteroids such as betamethasone, cortisone, dexamethasone, fludrocortisone, hydrocortisone (A-Hydrocort, Cortef), methylprednisolone (Medrol, Solu-Medrol), prednisolone (Omnipred, Orapred, Prelone), prednisone (Prednisone Intensol), and triamcinolone (Aristospan, Kenalog)
• Dextromethorphan/quinidine (Nuedexta)
• Diabetes medicines such as glipizide (Glucotrol), glyburide (Glynase), insulin, metformin (Fortamet, Glucophage, Riomet), pioglitazone (Actos), and rosiglitazone (Avandia)
• Diazoxide (Proglycem)
• Digoxin (Lanoxin)
• Diuretics (water pills) such as amiloride, amiloride/hydrochlorothiazide, bumetanide, furosemide (Lasix), hydrochlorothiazide (Microzide), spironolactone (Aldactone), spironolactone/hydrochlorothiazide (Aldactazide), torsemide (Demadex), triamterene (Dyrenium), and triamterene/hydrochlorothiazide (Dyazide, Maxzide)
• Eliglustat (Cerdelga)
• Epinephrine (Adrenalin, Asthmanefrin, Auvi-Q, EpiPen)
• Erectile dysfunction medicines such as avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra, Staxyn)
• Ergot medicines such as bromocriptine (Cycloset, Parlodel), dihydroergotamine (D.H.E. 45, Migranal), and ergotamine (Ergomar)
• Fingolimod (Gilenya)
• Flibanserin (Addyi)
• HIV medicines such as cobicistat (Tybost), darunavir (Prezista), lopinavir/ritonavir (Kaletra), ritonavir (Norvir), and saquinavir (Invirase)
• Immunosuppressants such as cyclosporine (Gengraf, Neoral, Sandimmune) and tacrolimus (Astagraf, Prograf, Protopic)
• Lithium (Lithobid)
• Lumacaftor/ivacaftor (Orkambi)
• MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
• Medicines to treat breathing or lung problems such as albuterol (ProAir, Proventil, Ventolin), levalbuterol (Xopenex), pirbuterol (Maxair), and theophylline
• Medicines to treat or prevent blood clots such as dipyridamole (Persantine) and warfarin (Coumadin)
• Mefloquine
• Midodrine
• Mirabegron (Myrbetriq)
• Narcotic pain medicines such as codeine, hydrocodone (Hysingla, Zohydro), hydromorphone (Dilaudid, Exalgo), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin), oxycodone (OxyContin, Roxicodone), and oxycodone/acetaminophen (Percocet, Roxicet)
• Natural remedies such as bayberry, black cohosh, blue cohosh, California poppy, cayenne, ephedra, garlic, ginger, ginseng, goldenseal, hawthorn, licorice, shepherd's purse, St. John's wort, and yohimbe
• Nausea medicines such as prochlorperazine (Compro) and promethazine
• Nitrate medicines such as isosorbide (Dilatrate, Isordil, Monoket) and nitroglycerin (Minitran, Nitro-Dur, Nitrostat)
• Nonsteroidal anti-inflammatory medicines (NSAIDs) such as celecoxib (Celebrex), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen, nabumetone (Relafen), and naproxen (Aleve, Anaprox, Naprelan)
• Other beta blockers such as acebutolol (Sectral), betaxolol, carteolol, carvedilol (Coreg), esmolol (Brevibloc), labetalol (Trandate), pindolol, sotalol (Betapace, Sorine), and timolol
• Other blood pressure medicines such as hydralazine, methyldopa, minoxidil, and reserpine
• Paroxetine (Brisdelle, Paxil, Pexeva)
• Quinine
• Ranolazine (Ranexa)
• Stimulants such as amphetamine/dextroamphetamine (Adderall), dextroamphetamine (Dexedrine), and methamphetamine (Desoxyn)
• Tizanidine (Zanaflex)
• Topiramate (Qudexy, Topamax, Trokendi)

Do not drink alcohol while you are taking this medicine unless your healthcare provider approves.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.