Oxybutynin, Gel

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KEY POINTS

• This medicine is put on the skin to treat the symptoms of urinary frequency, urinary urgency, urinary leakage, and incontinence. Use it exactly as directed.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antispasmodic; anticholinergic

Generic and brand names: oxybutynin, gel; Gelnique Gel

What is this medicine used for?

This medicine is a gel that is put on your skin. It treats the symptoms of overactive bladder (urinary frequency, urinary urgency, urinary leakage, and incontinence).

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• A blockage in the intestines, Crohn's disease, ulcerative colitis, or severe constipation
• Asthma or COPD
• Dementia
• Gastroesophageal reflux disease (GERD), hiatal hernia, or esophagitis (trouble swallowing)
• Glaucoma
• Heart problem such as heart failure, an irregular heartbeat, or a fast heartbeat
• High blood pressure
• Kidney or liver disease
• Mental health problems such as hallucinations or delusions
• Muscle diseases such as myasthenia gravis or Parkinson’s disease
• Nerve problems from diabetes, alcohol abuse, or injury
• Thyroid problems
• Trouble urinating or an enlarged prostate gland

Tell your healthcare provider if you take medicines that can irritate your esophagus such as alendronate (Fosamax) or risedronate (Actonel).

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Carefully read the directions that come in the medicine package. Use this medicine exactly as directed by your healthcare provider. Do not use more medicine or use it more often than prescribed. If you are not sure about how to use the medicine, ask your healthcare provider or pharmacist to explain or demonstrate.

Check with your healthcare provider before using this medicine in children under age 18.

Wash the area where the medicine will be applied with mild soap and water. Let the area to dry completely. Wash your hands before and after using this medicine. Use the medicine on dry skin that does not have any sores, rash, scars, tattoos, or irritation, or has been recently shaved. You may use the medicine on your stomach, upper arms, shoulders, or thighs. Change the area where you use the medicine every day to prevent a rash. Do not use this medicine on your breasts or genitals.

Wear clothing over the area where you use the medicine to keep other people from having contact with the medicine.

Do not take a bath, swim, shower, exercise, or get the application site wet for 1 hour after you apply your dose. This medicine may be used with sunscreen.

This medicine contains alcohol and is flammable. Avoid fire, flames, or smoking until the medicine has dried.

Avoid getting this medicine in or near your eyes, nose, or mouth. If you accidentally get this medicine in your eyes, rinse your eyes well right away with warm water.

What if I miss a dose?

If you miss a dose, apply it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and apply the next one as directed. Do not apply double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: restlessness, tingling, fever, flushing, irregular heartbeat, vomiting, decreased urination, fast heartbeat, confusion.

What should I watch out for?

Dry mouth and constipation are common side effects of this medicine. If these become bothersome, contact your healthcare provider.

This medicine may cause blurred vision, dizziness, or drowsiness. Do not drive or operate machinery unless you are fully alert and able to see clearly. You may feel dizzy or faint when you get up quickly after sitting or lying down. Getting up slowly may help.

You may sweat less while you are taking this medicine. Avoid extreme heat, saunas, hot tubs, and exercising too much. You can overheat which can cause heat stroke.

This medicine may make your eyes more sensitive to light. Wear sunglasses to help protect your eyes.

This medicine increases the effects of alcohol and other medicines that slow down your nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.

Adults over the age of 65 may be at greater risk for side effects such as nervousness or drowsiness. Talk with your healthcare provider about this.

Contact your healthcare provider if your condition does not improve or if it gets worse. Keep appointments for follow up visits.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; chest pain or tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Severe skin rash that doesn't go away; severe dizziness or vision problems; trouble urinating or painful urination; decreased sweating; trouble swallowing.

Other: Dry mouth, itching, redness, rash where the medicine is applied, diarrhea, constipation, abdominal pain, nausea, gas, drowsiness, tiredness, dizziness, blurred vision, headache, flushing.

What products might interact with this medicine?

Medicines that cause dry mouth, constipation, or drowsiness may increase your risk of side effects. When you take this medicine with other medicines, it could change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Alcohol
• Alzheimer’s disease medicines such as donepezil (Aricept), galantamine (Razadyne), and rivastigmine (Exelon)
• Antianxiety medicines such as alprazolam (Xanax), chlordiazepoxide, clorazepate (Gen-Xene, Tranxene), diazepam (Valium), lorazepam (Ativan), midazolam (Versed), and oxazepam
• Antibiotics such as clarithromycin (Biaxin) and erythromycin (E.E.S., Ery-Tab, Erythrocin)
• Anticholinergic medicines such as atropine/diphenoxylate (Lomotil), benztropine (Cogentin), dicyclomine (Bentyl), hyoscyamine (HyoMax, Levbid, Levsin), methscopolamine (Pamine), propantheline, and trihexyphenidyl
• Antifungal medicines such as itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend)
• Antihistamines such as chlorpheniramine (Chlor-Trimeton), diphenhydramine (Benadryl), and meclizine (Dramamine)
• Antipsychotic medicines such as chlorpromazine, clozapine, fluphenazine, olanzapine (Zyprexa), prochlorperazine (Compro), quetiapine (Seroquel), risperidone (Risperdal), thioridazine, and ziprasidone (Geodon)
• Corticosteroids such as betamethasone (Celestone), cortisone, dexamethasone, fludrocortisone, hydrocortisone (A-Hydrocort, Cortef), methylprednisolone (Medrol, Solu-Medrol), prednisolone (Omnipred, Orapred, Prelone), prednisone (Prednisone Intensol), and triamcinolone (Aristospan, Kenalog)
• Decongestants such as oxymetazoline (Afrin, Dristan), phenylephrine (Neo-Synephrine, Sudafed PE), and pseudoephedrine (Sudafed)
• Digoxin (Lanoxin)
• Doxepin (Silenor)
• Hydroxyzine (Vistaril)
• MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
• Medicines to treat breathing or lung problems such as ipratropium (Atrovent) and tiotropium (Spiriva)
• Metoclopramide (Metozolv, Reglan)
• Muscle relaxants such as baclofen (Lioresal), carisoprodol (Soma), and cyclobenzaprine (Amrix)
• Natural remedies such as gotu kola, kava, St. John's wort, and valerian
• Nitrate medicines such as isosorbide (Dilatrate, Isordil, Monoket) and nitroglycerin (Minitran, Nitro-Dur, Nitrostat)
• Osteoporosis medicines such as alendronate (Fosamax), ibandronate (Boniva), and risedronate (Actonel, Atelvia)
• Other bladder control medicines such as darifenacin (Enablex), flavoxate (Urispas), solifenacin (VESIcare), and tolterodine (Detrol)
• Pain medicines such as codeine, hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), morphine (Kadian, MS Contin), oxycodone (OxyContin, Roxicodone), and tapentadol (Nucynta)
• Parkinson’s disease medicines such as amantadine (Symmetrel) and levodopa/carbidopa (Duopa, Rytary, Sinemet)
• Potassium supplements or salt substitutes that contain potassium
• Pramlintide (Symlin)
• Promethazine
• Sleeping pills such as flurazepam, temazepam (Restoril), triazolam (Halcion), zaleplon (Sonata), and zolpidem (Ambien, Edluar, Intermezzo)
• Tricyclic antidepressants such as amitriptyline, desipramine (Norpramin), imipramine (Tofranil), and nortriptyline (Pamelor)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Protect it from heat, high humidity, and bright light.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.