Pertuzumab, Injection

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KEY POINTS

• This medicine is given by IV to treat HER2-positive breast cancer.
• You may get infections more easily when you are taking this medicine.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine can cause heart damage, severe allergic reactions, or infusion-related reactions. This medicine may also cause other unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antineoplastic (anticancer); anti-HER2; monoclonal antibody

Generic and brand names: pertuzumab, injection; Perjeta

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein) to treat HER2-positive breast cancer that has spread to other parts of the body. It is used with other medicines.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine, food, preservative, or dye
• Heart disease, heart failure, heart attack, or irregular heartbeat
• High blood pressure

Tell your provider if you have recently had chemotherapy or radiation therapy. Also tell your provider if you have any kind of infection.

Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your healthcare provider. Do not become pregnant during treatment with this medicine. Use an effective birth control method while you are taking this medicine and for 7 months after your last dose. Talk with your healthcare provider about effective birth control methods. If you become pregnant, contact your healthcare provider right away. Do not breast-feed a baby during treatment with this medicine.

How do I use it?

You may be given these infusions in your healthcare provider's office or at a clinic where you will be watched carefully. The infusions are usually given every 3 weeks. Keep all appointments for these infusions.

What should I watch out for?

This medicine can cause severe allergic reactions or other infusion-related reactions during the infusion or on the day of infusion. Your healthcare provider may interrupt or slow the infusion, and give you medicine to treat the reaction. Tell your healthcare provider right away or get emergency medical care if you have symptoms such as:

• Hives, rash, or itching
• Tightness in your chest
• Swelling of your lips, tongue, and throat
• Fever and chills
• Severe headache or muscle pain
• Vomiting

This medicine can cause heart damage. Contact your healthcare provider right away if you wake up at night with chest pain, shortness of breath, or trouble breathing; swelling of the feet, ankles, or legs, or any unexplained swelling.

You need to have checkups and blood tests regularly to see how this medicine affects you. Keep all appointments.

You may get infections more easily when you are taking this medicine. Contact your healthcare provider right away if you develop a fever or ANY other symptoms of infection. Stay away from people with colds, flu, or other infections. Also, do not have any vaccines without getting your healthcare provider's approval first.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you have received this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Waking up at night with shortness of breath or trouble breathing; chest pain; swelling of the feet, ankles, or legs, or any unexplained swelling; unexplained fever or sore throat; severe tiredness or weakness; cough; fast or irregular heartbeat; numbness or tingling in your hands or feet; severe nausea, vomiting, or diarrhea; unusual bruising or bleeding; severe dizziness or fainting.

Other: Diarrhea, nausea, vomiting, stomach pain, loss of appetite, dizziness, trouble sleeping, runny nose, muscle pain, headache, hair loss, dry skin, sores in your mouth or on your lips, change in sense of taste, tiredness, weakness; skin redness, soreness, or peeling on the palms of your hands or soles of your feet.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Belimumab (Benlysta)
• Cancer medicines such as cyclophosphamide (Cytoxan), daunorubicin (Cerubidine), doxorubicin (Doxil), epirubicin (Ellence), idarubicin (Idamycin), mitoxantrone (Novantrone), and paclitaxel (Abraxane, Taxol)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.