Pralatrexate, Injection

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KEY POINTS

• This medicine is given by injection to treat peripheral T-cell lymphoma.
• You may get infections more easily when you are taking this medicine.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antineoplastic (anticancer)

Generic and brand names: pralatrexate, injection; Folotyn

What is this medicine used for?

This medicine is given by injection to treat people with a type of cancer called Peripheral T-cell Lymphoma that does not go away, gets worse, or comes back after other cancer treatment.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Gout
• Kidney disease
• Liver disease

Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your healthcare provider. Do not become pregnant during treatment with this medicine. If you become pregnant, contact your healthcare provider right away. Do not breast-feed while you are receiving this medicine.

How do I use it?

This medicine is given by IV injection. How long you will need this treatment will be determined by your healthcare provider. Your healthcare provider may also give you a vitamin B12 injection (shot) and folic acid tablets to take before and during treatment with this medicine. Talk with your healthcare provider about this.

What should I watch out for?

You need to have lab tests to determine how the medicine is affecting you. Keep all appointments for these tests.

You will need to take exact amounts of folic acid and vitamin B12 before and during treatment with this medicine. Talk with your provider about this.

Follow your provider’s instructions about how much liquid to drink while you are receiving this medicine.

You may get infections more easily when you are taking this medicine or bleed more easily. Stay away from people with colds, flu, or other infections. Also, do not have any vaccines without getting your healthcare provider's approval first.

Do not drink alcohol or take aspirin while receiving this medicine. It may increase the risk of bleeding. Report any unusual bruising or bleeding to your healthcare provider.

This medicine may cause redness and sores of the lining of your mouth, lips, throat, digestive tract, and genitals. Talk with your provider about this.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Chills, fever, shortness of breath, cough, sore throat, sores in your mouth or throat, severe weakness or tiredness, unusual bruising or bleeding, irregular or fast heartbeat, fainting, chest pain, severe nausea or vomiting, severe diarrhea, burning on urination, trouble passing urine, muscle aches, worsening of skin problems, swelling of arms or legs.

Other: Nausea; vomiting; constipation; loss of appetite; change in your sense of taste; diarrhea; tiredness; weakness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Echinacea
• Nonsteroidal anti-inflammatory medicines (NSAIDs) such as celecoxib (Celebrex), diclofenac (Cambia, Voltaren, Zipsor), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen, ketorolac, meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Anaprox, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)
• Probenecid
• Salicylates such as aminosalicylic acid (Paser), aspirin, choline magnesium trisalicylate (Trilisate), choline salicylate (Arthropan), and salsalate (Amigesic, Disalcid, Salflex)
• Sulfamethoxazole/trimethoprim (Bactrim, Septra)
• Vaccines

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.