Probenecid/Colchicine, Oral

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KEY POINTS

• This medicine is taken by mouth to treat gout or gouty arthritis. This is a very strong medicine. Take it exactly as directed.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antigout

Generic and brand names: probenecid/colchicine, oral

What is this medicine used for?

This medicine is taken by mouth to treat gout or gouty arthritis by removing excess uric acid from your body.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Bleeding problems or a blood disorder
• Heart disease
• Kidney disease or kidney stones
• Liver disease
• Ulcers or stomach problems

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine, and any other medicines for gout, exactly as your healthcare provider prescribes. Do not take more or less or take it longer than prescribed.

Do not use this medicine in children under age of 2 years.

Take the medicine with a full glass of water. You may take this medicine with or without food. Taking it with meals may lessen the chance the medicine will upset your stomach.

You need to drink plenty of water or other liquid (10 glasses a day, or as instructed by your healthcare provider) to prevent kidney stones. Talk with your healthcare provider about this.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: vomiting, stomach pain, diarrhea, muscle weakness, burning in your throat or stomach, flushing, trouble breathing, trouble urinating, blood in your urine, confusion, seizures, nausea, coma.

What should I watch out for?

This is a very strong medicine. It must be used only as directed. Do not use this medicine for any other condition unless your healthcare provider approves.

Follow the diet program your healthcare provider recommends. Alcohol and foods such as beef, chicken, pork, liver, anchovies, and sardines may cause gout attacks. Talk with your healthcare provider about this.

It may take time for this medicine to stop all gout attacks. The attacks will decrease gradually over a period of time. You must take it regularly for it to work. Your healthcare provider will prescribe other medicines to treat an attack.

Aspirin and other salicylates make this medicine less effective. Alcohol increases uric acid in the blood. Do not take aspirin or drink alcohol while you are taking this medicine. If you have any questions, ask your healthcare provider.

This medicine may make you dizzy. Do not drive or operate machinery unless you are fully alert.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

Your healthcare provider should check you regularly to see how this medicine affects you. You may need to have blood tests. Keep all appointments.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Unexplained sore throat, cough, or fever; unusual bruising or bleeding; unusual tiredness or weakness; muscle pain or weakness; numbness or tingling in fingers or toes; severe diarrhea, nausea, or vomiting; severe stomach pain; fast or irregular heartbeat; painful or decreased urination; low back pain; skin rash; bloody or tarry bowel movements; blood in urine; pale or gray color to your lips, tongue, or palms of your hands; yellowing of your skin or eyes.

Other: Loss of appetite, headache, mild diarrhea, mild nausea or vomiting, stomach pain or cramping, dizziness, hair loss, sore gums, flushing.

What products might interact with this medicine?

Taking certain medicines while taking this medicine can cause serious side effects or death. Even medicines that you take for a short time can be dangerous. Tell your healthcare provider and pharmacist about any other prescription or nonprescription medicines, or natural remedies that you take. Do not take any other medicines unless your healthcare provider approves. Talk to your healthcare provider or pharmacist before taking any new medicine.

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Acetaminophen and medicines that contain acetaminophen
• Alcohol
• Antibiotics such as amoxicillin (Amoxil, Moxatag), amoxicillin/clavulanate potassium (Augmentin), ampicillin, cefaclor, cefadroxil (Duricef), cefditoren (Spectracef), ceftazidime/avibactam (Avycaz), cephalexin (Keflex), chloramphenicol, ciprofloxacin (Cipro), clarithromycin (Biaxin), dapsone, dicloxacillin, doripenem (Doribax), ertapenem (Invanz), erythromycin (E.E.S., Ery-Tab, Erythrocin), gemifloxacin (Factive), imipenem (Primaxin), meropenem (Merrem), nitrofurantoin (Furadantin, Macrobid, Macrodantin), penicillin (Penicillin-VK), pyrazinamide, rifampin (Rifadin), telithromycin (Ketek), and tetracycline
• Antidepressants such as desipramine (Norpramin) and nefazodone
• Antifungal medicines such as clotrimazole, fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend)
• Antipsychotic medicines such as haloperidol (Haldol) and iloperidone (Fanapt)
• Antiviral medicines such as ganciclovir (Cytovene), ombitasvir/paritaprevir/ritonavir/dasabuvir (Viekira), oseltamivir (Tamiflu), simeprevir (Olysio), and valganciclovir (Valcyte)
• Aprepitant (Emend)
• Aspirin and other salicylates
• Cancer medicines such as abiraterone (Zytiga), axitinib (Inlyta), bicalutamide (Casodex), crizotinib (Xalkori), dasatinib (Sprycel), ibrutinib (Imbruvica), idelalisib (Zydelig), imatinib (Gleevec), lapatinib (Tykerb), nilotinib (Tasigna), osimertinib (Tagrisso), palbociclib (Ibrance), sunitinib (Sutent), tamoxifen, vandetanib (Caprelsa), and vemurafenib (Zelboraf)
• Cholesterol-lowering medicines such as atorvastatin (Lipitor), fenofibrate (Antara, Fenoglide, Lipofen, TriCor, Triglide), fluvastatin (Lescol), gemfibrozil (Lopid), lomitapide (Juxtapid), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor)
• Cimetidine (Tagamet)
• Conivaptan (Vaprisol)
• Diabetes medicines such as chlorpropamide, glimepiride (Amaryl), glipizide (Glucotrol), glyburide (Glynase), tolazamide, and tolbutamide
• Dipyridamole (Persantine)
• Diuretics (water pills) such as bumetanide, furosemide (Lasix), and torsemide (Demadex)
• Entacapone (Comtan)
• Heart medicines such as amiodarone (Cordarone, Pacerone), carvedilol (Coreg), digoxin (Lanoxin), diltiazem (Cardizem, Cartia, Tiazac), dronedarone (Multaq), nicardipine (Cardene), quinidine, ranolazine (Ranexa), reserpine, and verapamil (Calan, Covera, Verelan)
• HIV medicines such as atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva), elvitegravir/cobicistat/emtricitabine/tenofovir (Stribild), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir/ritonavir (Kaletra), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), saquinavir (Invirase), tipranavir (Aptivus), and zidovudine (Retrovir)
• Immunosuppressants such as cyclosporine (Gengraf, Neoral, Sandimmune), mycophenolate (CellCept, Myfortic), and tacrolimus (Astagraf, Prograf, Protopic)
• Ivacaftor (Kalydeco)
• Lorazepam (Ativan)
• Mefloquine
• Methotrexate (Otrexup, Rasuvo, Rheumatrex, Trexall)
• Nonsteroidal anti-inflammatory medicines (NSAIDs) such as celecoxib (Celebrex), diclofenac (Cambia, Voltaren, Zipsor), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen, ketorolac, nabumetone (Relafen), naproxen (Aleve, Anaprox, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)
• Pegloticase (Krystexxa)
• Pralatrexate (Folotyn)
• Propranolol (Hemangeol, Inderal, InnoPran)
• Quinine
• Red yeast rice
• Sulfamethoxazole/trimethoprim (Bactrim, Septra)
• Ulipristal (ella)
• Vitamin B-12

Do NOT eat or drink products that contain grapefruit, Seville oranges, and tangelos at any time while you are taking this medicine. These fruits and juices affect the way this medicine works and increase your risk of serious side effects. Talk with your healthcare provider or pharmacist about this.

Do not drink alcohol while you are taking this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.