Tedizolid, Oral/Injection

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KEY POINTS

• This medicine is taken by mouth or given by IV to treat serious bacterial infections. Take it exactly as directed.
• This medicine may cause severe diarrhea or other unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antibiotic

Generic and brand names: tedizolid, injection; tedizolid, oral; Sivextro

What is this medicine used for?

This medicine is taken by mouth, or given by injection to treat serious bacterial infections.

This medicine will not cure viral infections such as colds or flu.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Bone marrow problems

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

This medicine comes in 2 forms:

• Tablets to take by mouth
• IV infusions (slow drip through a needle into a large vein)

Your healthcare provider will usually give infusions of this medicine.

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes for as long as prescribed. If you stop taking it too soon, the infection may return.

Check with your healthcare provider before using this medicine in children under age 18.

You may take the tablets with or without food.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is less than 8 hours until the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

Symptoms of an acute overdose have not been reported.

What should I watch out for?

This medicine may cause or worsen diarrhea. If you develop severe diarrhea or diarrhea that lasts more than 2 or 3 days while taking this medicine, or for several weeks after you stop taking this medicine, contact your healthcare provider right away. Do not take medicine to treat diarrhea without your provider's approval.

This medicine may make you dizzy. Do not drive or operate machinery unless you are fully alert. Drinking alcohol may make it worse. Do not drink alcohol unless your healthcare provider approves.

If your symptoms do not improve within a few days or if they get worse, contact your healthcare provider.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (Report these to your healthcare provider right away.): Severe nausea, vomiting, or diarrhea; watery or bloody bowel movements, with or without stomach cramps and fever; unusual bruising or bleeding; unusual tiredness or weakness; fast or irregular heartbeat; chest pain; vision changes.

Other: Mild nausea, vomiting, or diarrhea; headache; dizziness; trouble sleeping; mild pain or redness at the infusion site.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Alcohol
• Allergy, cold, or cough medicines such as dextromethorphan, naphazoline, oxymetazoline (Afrin, Dristan), phenylephrine (Neo-Synephrine, Sudafed PE), pseudoephedrine (Sudafed), and tetrahydrozoline (Tyzine, Visine)
• Antidepressants such as amitriptyline, citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), imipramine (Tofranil), mirtazapine (Remeron), nefazodone, sertraline (Zoloft), trazodone, and venlafaxine (Effexor)
• Bupropion (Aplenzin, Forfivo, Wellbutrin, Buproban, Zyban)
• Buspirone
• Doxepin (Silenor)
• Linezolid (Zyvox)
• Lithium (Lithobid)
• MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
• Migraine medicines such as almotriptan (Axert), dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar), rizatriptan (Maxalt), sumatriptan (Alsuma, Imitrex, Sumavel), and zolmitriptan (Zomig)
• Muscle relaxants such as cyclobenzaprine (Amrix) and metaxalone (Skelaxin)
• Pain medicines such as buprenorphine (Buprenex, Butrans), fentanyl (Abstral, Actiq, Duragesic, Fentora, Sublimaze), hydrocodone (Hysingla, Zohydro), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin), oxycodone (OxyContin, Roxicodone), oxymorphone (Opana, Opana ER), tapentadol (Nucynta), and tramadol (ConZip, Ultram)
• Parkinson’s disease medicines such as bromocriptine (Cycloset, Parlodel), entacapone (Comtan), levodopa/carbidopa (Duopa, Rytary, Sinemet), rasagiline (Azilect), and tolcapone (Tasmar)
• Paroxetine (Brisdelle, Paxil, Pexeva)
• Procarbazine (Matulane)
• Products that contain methylene blue (Hyophen, Prosed DS, Urophen, Uta)
• Stimulants and diet pills such as atomoxetine (Strattera), benzphetamine (Regimex), dextroamphetamine (Dexedrine), diethylpropion (Tenuate), methamphetamine (Desoxyn), methylphenidate (Concerta, Daytrana, Metadate, Ritalin), phendimetrazine, and phentermine (Adipex-P, Suprenza)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store the tablets at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.