Tinidazole, Oral

________________________________________________________________________

KEY POINTS

• This medicine is taken by mouth to treat diseases caused by bacteria or parasites, including certain sexually transmitted diseases. Take it exactly as directed.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

________________________________________________________________________

What are other names for this medicine?

Type of medicine: antimicrobial; anti-infective

Generic and brand names: tinidazole, oral; Tindamax

What is this medicine used for?

This medicine is taken by mouth to treat diseases caused by bacteria or parasites, including certain sexually transmitted diseases. This medicine does not treat viral infections like the common cold.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Be sure to tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• A blood disorder
• Liver or kidney disease
• Nerve disease
• Seizures

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. This medicine should not be used in the first 3 months of pregnancy. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine and for 3 days after taking the last dose without your healthcare provider's approval.

How do I use it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more or less or take it longer than prescribed. Do not stop taking this medicine without your healthcare provider's approval, even if you feel better.

Take this medicine with food. Taking it with meals may lessen the chance the drug will upset your stomach.

Check with your healthcare provider before using this medicine in children under age 3.

If you are unable to swallow the tablets, your pharmacist can make a liquid using the tablets. Talk with your healthcare provider about this. If you are using the liquid, shake the bottle well before pouring a dose. Use a specially marked measuring device to measure each dose. The average household teaspoon may not hold the right amount of liquid.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

Symptoms of an acute overdose have not been reported.

What should I watch out for?

This medicine may make you dizzy. Do not drive or operate machinery unless you are fully alert.

Another medicine similar to this medicine has caused cancer in some laboratory animals. It is not known whether people who take this medicine have an increased risk of cancer. Talk with your healthcare provider about this.

Do not drink alcohol or use any products or other medicines that contain alcohol while taking this medicine and for 3 days after you stop taking the medicine. Before you buy any medicines, ask your pharmacist if they contain alcohol. Alcohol can cause an unpleasant reaction with this medicine such as headache, flushing, sweating, fast heartbeat, nausea, and vomiting.

This medicine may cause a vaginal yeast infection. Tell your healthcare provider if you have an unusual vaginal odor, discharge, or itching. You may need another medicine to treat the infection.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; tightness in your chest; swelling of your lips, tongue, or throat; trouble breathing).

Serious (Report these to your healthcare provider right away.): Seizures; numbness or tingling in arms or legs; shortness of breath; chest pain; unexplained fever or sore throat; severe diarrhea; unusual bruising or bleeding; severe tiredness or weakness; difficult or painful urination; fast or irregular heartbeat; vaginal itching or discharge; blistered peeling or red skin; severe rash or itching.

Other: Headache; nausea; vomiting; diarrhea; constipation; loss of appetite; bitter or metallic taste; stomach pain; trouble sleeping; flushing; sweating; dry mouth; change in the color of your tongue; joint or muscle pain; mild dizziness, tiredness, or itching.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Alcohol
• Antibiotics such as clarithromycin (Biaxin), erythromycin (E.E.S., Ery-Tab, Erythrocin), rifabutin (Mycobutin), rifampin (Rifadin), and telithromycin (Ketek)
• Antiseizure medicines such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), clobazam (Onfi), oxcarbazepine (Trileptal), phenobarbital, phenytoin (Dilantin, Phenytek), and primidone (Mysoline)
• Cholestyramine (Prevalite)
• Cimetidine (Tagamet)
• Conivaptan (Vaprisol)
• Dexamethasone
• Disulfiram (Antabuse) (Do not take this medicine and disulfiram within 14 days of each other.)
• Enzalutamide (Xtandi)
• Fluorouracil (Adrucil, Carac, Efudex, Fluoroplex)
• HIV medicines such as atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva), elvitegravir/cobicistat/emtricitabine/tenofovir (Stribild), etravirine (Intelence), indinavir (Crixivan), lopinavir/ritonavir (Kaletra), maraviroc (Selzentry), nelfinavir (Viracept), nevirapine (Viramune), rilpivirine (Edurant), ritonavir (Norvir), saquinavir (Invirase), tipranavir (Aptivus), and zidovudine (Retrovir)
• Immunosuppressants such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Prograf, Protopic)
• Lithium (Lithobid)
• Loperamide (Imodium)
• Other antifungal medicines such as amphotericin b (Abelcet, AmBisome, Amphotec), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend)
• St. John's wort
• Warfarin (Coumadin)

Do not drink alcohol while you are taking this medicine and for 3 days after you stop taking the medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

Shake the liquid suspension well before using. Discard any unused liquid medicine after 7 days.

---

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.