Triptorelin Pamoate, Injection

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KEY POINTS

• This medicine is given by IV to treat prostate cancer.
• This medicine must not be used by women who are pregnant, may become pregnant, or are breastfeeding.
• Keep all appointments for tests to see how this medicine affects you.
• This medicine may increase your risk for a heart attack or stroke. This medicine may cause other unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antineoplastic (anticancer); gonadotropin hormone agonist

Generic and brand names: triptorelin pamoate, injection; Trelstar Depot; Trelstar LA

What is this medicine used for?

This medicine is given by injection (shot) to treat advanced prostate cancer. It may be used instead of surgery or estrogen treatment.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• A stroke or transient ischemic attack (TIA)
• Cancer in your spine
• Diabetes
• Heart disease or a heart attack
• High blood pressure
• High cholesterol
• Liver or kidney disease
• Long QT syndrome (problems with electrical activity in the heart muscle)
• Low levels of calcium, magnesium, or potassium in your blood
• Trouble urinating

Tell your provider if you smoke cigarettes.

Females of childbearing age: Do not take this medicine if you are pregnant. This medicine has been reported to cause birth defects. Stop taking this medicine at the first sign that you may be pregnant and contact your healthcare provider right away. Do not breast-feed while taking this medicine.

How do I use it?

These shots are given by a healthcare provider. This is a slow-release medicine that will last several weeks. The shots are given into a muscle. Keep all appointments for shots.

What should I watch out for?

During the first weeks of treatment the signs and symptoms of prostate cancer may get worse. If you have bone pain or neuropathy (numbness and pain in your feet or hands), are unable to urinate, or notice blood in your urine, contact your healthcare provider right away.

This medicine may increase your risk for a heart attack or stroke. Contact your healthcare provider right away if you have dizziness, lightheadedness, fainting, or abnormal heartbeats.

This medicine may make you dizzy. Do not drive or operate machinery until you are fully alert. Talk to your healthcare provider about this.

You will need to have blood tests to check how well you are responding to this medicine. Keep all appointments for tests.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you have received this medicine.

You may develop diabetes when you take this medicine. If you already have diabetes, it may get worse. Talk with your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat); sudden weakness, numbness, or tingling, especially on one side of your body; sudden or severe headache; sudden trouble with vision, speech, balance, or walking.

Serious (Report these to your healthcare provider right away.): Bone pain, numbness and pain in your legs, feet or hands, trouble urinating or pain while urinating, blood in the urine, unusual weakness, slow or irregular heartbeat, severe dizziness or fainting, unexplained swelling, seizures.

Other: Hot flashes, headache, change in sexual ability or desire, injection site pain, lightheadedness, dizziness, trouble sleeping, nausea, vomiting, diarrhea, breast pain or swelling.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Antibiotics such as ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (E.E.S., Ery-Tab, Erythrocin), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam), and telithromycin (Ketek)
• Antidepressants such as amitriptyline, citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), sertraline (Zoloft), and trazodone
• Antifungal medicines such as fluconazole (Diflucan) and voriconazole (Vfend)
• Antipsychotic medicines such as asenapine (Saphris), chlorpromazine, clozapine (Clozaril, FazaClo), fluphenazine, haloperidol (Haldol), iloperidone (Fanapt), olanzapine (Zyprexa), paliperidone (Invega), perphenazine, pimozide (Orap), prochlorperazine (Compro), risperidone (Risperdal), thioridazine, trifluoperazine, and ziprasidone (Geodon)
• Cancer medicines such as arsenic trioxide (Trisenox), crizotinib (Xalkori), lapatinib (Tykerb), nilotinib (Tasigna), sorafenib (Nexavar), sunitinib (Sutent), toremifene (Fareston), vandetanib (Caprelsa), and vemurafenib (Zelboraf)
• Dextromethorphan/quinidine (Nuedexta)
• Doxepin (Silenor)
• Estrogen or testosterone
• Fingolimod (Gilenya)
• Heart medicines such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), flecainide, ibutilide (Corvert), ivabradine (Corlanor), procainamide, propafenone (Rythmol), quinidine, ranolazine (Ranexa), and sotalol (Betapace, Sorine)
• Methadone (Dolophine, Methadose)
• Methyldopa
• Metoclopramide (Metozolv, Reglan)
• Natural remedies such as black cohosh, chasteberry, and DHEA
• Nausea medicines such as dolasetron (Anzemet), droperidol (Inapsine), and ondansetron (Zofran)
• Paroxetine (Brisdelle, Paxil, Pexeva)
• Quinine

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.