Tirofiban Hydrochloride, Injection

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KEY POINTS

• This medicine is given by IV infusion to treat certain types of angina or other heart conditions.
• This medicine may cause unwanted side effects. Tell your healthcare provider if you have any side effects that are serious, continue, or get worse.
• Tell all healthcare providers who treat you about all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take.

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What are other names for this medicine?

Type of medicine: antiplatelet

Generic and brand names: tirofiban hydrochloride, injection; Aggrastat

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein) to treat certain types of angina (chest pain) or other heart conditions. It may be given to you if you are having a medical procedure such as angiography and angioplasty.

This medicine is usually used along with shots of heparin.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I receive this medicine?

Tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• A stroke or transient ischemic attack (TIA)
• Bleeding in the brain, a brain tumor, or brain aneurysm
• Bleeding problems or thrombocytopenia (low platelet count in your blood)
• Heart problems
• High blood pressure
• Kidney disease
• Major surgery or a severe injury within the past month

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

IV infusions are given by your healthcare provider while you are in the hospital or other medical facility.

What should I watch out for?

The most common and serious side effect of this medicine is bleeding. Most bleeding happens at the site where the IV needle is inserted.

You will be closely watched to detect any bleeding. You will have blood tests regularly to see how this medicine affects you.

Do not drink alcohol while receiving this medicine without your healthcare provider’s approval. It may increase the risk of bleeding.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you have received this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat); sudden weakness, numbness, or tingling, especially on one side of your body; sudden or severe headache; sudden trouble with vision, speech, balance, or walking.

Serious (Report these to your healthcare provider right away.): Unusual bruising or bleeding; dark red spots under your skin; worsening chest pain; shortness of breath; severe dizziness or fainting; confusion; vomiting blood or material that looks like coffee grounds; sudden, severe pain in your head, neck, shoulders, legs, or back; severe nausea or vomiting; unexplained fever; slow heartbeat; blood in the urine or bowel movements.

Other: Nausea, mild headache, pelvic pain, dizziness, sweating.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Alcohol
• Aspirin and other salicylates
• Cancer medicines such as dasatinib (Sprycel), ibritumomab (Zevalin), ibrutinib (Imbruvica), and tositumomab (Bexxar)
• Deferasirox (Exjade, Jadenu)
• Medicines to treat or prevent blood clots such as abciximab (ReoPro), alteplase (Activase), anagrelide (Agrylin), apixaban (Eliquis), cilostazol (Pletal), clopidogrel (Plavix), dabigatran (Pradaxa), dalteparin (Fragmin), dipyridamole (Persantine), enoxaparin (Lovenox), fondaparinux (Arixtra), heparin, prasugrel (Effient), reteplase (Retavase), rivaroxaban (Xarelto), tenecteplase (TNKase), ticagrelor (Brilinta), vorapaxar (Zontivity), and warfarin (Coumadin)
• Medicines to treat pulmonary hypertension such as iloprost (Ventavis) and treprostinil (Remodulin, Tyvaso)
• Natural remedies such as agrimony, alfalfa, anise, arnica, bilberry, black cohosh, bladderwrack, bromelain, cat’s claw, dong quai, evening primrose oil, fenugreek, feverfew, fish oil, garlic, ginger, ginkgo biloba, ginseng, goldenseal, grape seed, green tea, horse chestnut, licorice, nettle, passion flower, pau d'arco, red clover, reishi, SAMe, St. John's wort, sweet clover, turmeric, and willow
• Nonsteroidal anti-inflammatory medicines (NSAIDs) such as celecoxib (Celebrex), diclofenac (Cambia, Voltaren, Zipsor), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen, ketorolac, nabumetone (Relafen), naproxen (Aleve, Anaprox, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)
• Paroxetine (Brisdelle, Paxil, Pexeva)
• Pentoxifylline
• SSRI antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), and sertraline (Zoloft)
• Vitamin E

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicines in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.